The Comprehensive Heart Health Panel includes: A Lipid Panel is the standard and most commonly ordered cholesterol test. It measures Total Cholesterol, LDL, HDL, Triglycerides, and VLDL. A CRP High Sensitivity test measures a protein which can be a risk factor for events like a heart attack or stroke.
Our Cardiac Health Panel gives insight into how a patient’s genetic predisposition to cardiac problems can help healthcare providers optimize diagnosis and treatment. Cardiovascular disease is a leading contributor to morbidity and mortality, with over 17 million deaths occurring annually worldwide. Risk increases in adults over the age of 60, and in part is attributable to inherited genetic makeup.
Cardiovascular disease – which includes coronary heart disease, cerebrovascular disease, peripheral artery disease, and atherosclerosis – is heavily influenced by factors such as insulin resistance, hypertension, dyslipidemia, inflammation, and coagulation properties.
Many of these factors can be mitigated by lifestyle changes including smoking cessation, increasing aerobic exercise, and eating a well-balanced diet, which can reduce the risk of catastrophic events such as myocardial infarction, or ischemic and hemorrhagic stroke. However, in some cases, particularly where family history of cardiovascular disease is prevalent, medications or more targeted lifestyle interventions are needed to better manage health outcomes.
Cardiac Health Panel Genetic Markers Include
|TEST CATEGORIES||EFFECTS ON CARDIAC HEALTH|
|ApoE||Impacts management of cholesterol levels and risk of heart attack, stroke, hypertension, and coronary disease|
|Factor II (Prothrombin)||Affects the body’s ability to form blood clots which is tied to the risk of many cardiovascular-related health outcomes|
|Factor V||Enhances body’s coagulability which leads to thromboembolisms|
|MTHFR||Contributes to increased levels of homocysteine, a known risk factor for heart disease, atherosclerosis, and peripheral neuropathy|
|9p21||Associated with cellular growth and proliferation in relation to atherosclerosis, arterial stiffness and coronary artery disease|
|eNOS/NOS3||Influences nitric oxide levels leading to risk of endothelial dysfunction, and many subsequent cardiovascular effects|
|SLCO1B1*5||Modulates the body’s ability to metabolize statin medications, which are commonly prescribed to improve cholesterol|
|AGT||Key to maintaining blood pressure, patients who carry this mutation may be at an increased risk of developing hypertension|
For Cardiac Pharmacogenetics, these SNPs are ordered as part of our PGx Comprehensive panel:
CYP2D6, CYP2C19, CYP2C9, CYP3A4, CYP3A5, VKOPC1
Ideal Candidates Have The Following Symptoms or Conditions
- Treatment-resistant hypertension
- Poor control over cholesterol levels
- Personal history of angina, DVT, PE, CHF, MI or CVA
- Introduction of new statin medications
- Family history of cardiovascular disease
- Stroke or heart disease in the young
- Idiopathic cardiovascular disease
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