Description
Our Mood Profile Panel identifies nutrient deficiencies that may contribute each patient’s susceptibility to mood disorders. About 350 million people worldwide suffer from behavioral health issues such as depression or anxiety. Although the physiological basis behind these crippling mood disorders is not completely understood, several biochemical factors (such as serotonin and dopamine) are scientifically proven to affect mental health and perceptions of panic or anxiety. Several genetic markers have been identified that affect metabolic pathways in the body involving dopamine, serotonin, epinephrine, and folate; all known to be associated with depression and anxiety.
The UMBRELLA Mood Profile Panel analyzes multiple genes to determine whether there are any identifiable mutations known to affect these pathways, providing information that can help patients manage the mood disorder specific to their genetic code.
Mood Profile Panel Genetic Markers Include
TEST CATEGORIES | EFFECTS ON MOOD PROFILE |
---|---|
COMT | Central to dopamine metabolism; Heavily associated with propensity to worry (Val158 Met) |
MTHFR | Key to maintaining levels of activated folate which may aid in preventing depression (c677T, A1298C) |
Vitamin B12 | Tests for a gene central to optimal B12 levels; B12 deficiency is a depression risk factor (FUT2) |
Vitamin D | Vitamin D helps mood regulation within the hippocampus, amygdala and thalamus regions of the brain (GC, NADSYN1/DHCR7, CYP2R1) |
Ideal Candidates Have The Following Symptoms Or Conditions
- Mood Disorders
- Compromised Diet
- High Stress Lifestyle
- Significant toxin exposure (environmental or diet)
Scientific References
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- Nissen J et al. Vitamin D Concentrations in Healthy Danish Children and Adults. PLOS One. 2014; 9(2):e89907.
- Foucan L et al. Polymorphisms in GC and NADSYN1 Genes are associated with vitamin D status and metabolic profile in non-diabetic adults. BMC Endocrine Disorders. 2013; 13:36.
- Wang T et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010; 376(9736):180-188.
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- Bjelland I et al. Folate, Vitamin B12, Homocysteine, and the MTHFR 677CT Polymorphism in Anxiety and Depression: The Hordaland Homocysteine Study. Arch Gen Psychiatry. 2003; 60(6):618-626.
- Beydoun MA et al. Serum folate, vitamin B-12 and homocysteine and their association with depressive symptoms among US adults. Psychosom Med. 2010;72(9):862-873.
- Refsum H et al. The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease. J Nutr. 2006; 136:1731S-1740S.
- Frosst P et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995; 10:111–113.
- Lewis SJ et al. The thermolabile variant of MTHFR is associated with depression in the British Women’s Heart and Health Study and a meta-analysis. Molecular Psychiatry. 2006; 11:352-360.
- Van der Put NM et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet. 1998; 62(5):1044–51.
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